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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis. | Available online http ccforum.eom content 13 3 R64 Research Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis Philipp Kumpers1 Matijs van Meurs2 3 Sascha David1 Grietje Molema3 Johan Bijzet3 Alexander Lukasz1 Frank Biertz4 Hermann Haller1 and Jan G Zijlstra2 Department of Nephrology Hypertension Hannover Medical School Carl-Neuberg-StraBe 1 30625 Hannover Germany department of Critical Care University Medical Center Groningen Hanzeplein 1 9713 GZ Groningen The Netherlands department of Pathology and Medical Biology University Medical Center Groningen Hanzeplein 19713 GZ Groningen The Netherlands department of Biometrics Hannover Medical School Carl-Neuberg-StraBe 1 30625 Hannover Germany Contributed equally Corresponding author Philipp Kumpers kuempers.philipp@mh-hannover.de Received 12 Feb 2009 Revisions requested 3 Apr 2009 Revisions received 21 Apr 2009 Accepted 5 May 2009 Published 5 May 2009 Critical Care 2009 13 R64 doi 10.1186 cc7866 This article is online at http ccforum.com content 13 3 R64 2009 Kumpers et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Endothelial activation leading to vascular barrier breakdown denotes a devastating event in sepsis. Angiopoietin Ang -2 a circulating antagonistic ligand of the endothelial specific Tie2 receptor is rapidly released from Weibel-Palade and has been identified as a non-redundant gatekeeper of endothelial activation. We aimed to study the time course of Ang-2 release during human experimental endotoxemia the association of Ang-2 with soluble adhesion molecules and inflammatory cytokines and the early time course of Ang-2 release during sepsis in critically ill patients. Methods In 22 healthy .