TAILIEUCHUNG - Báo cáo y học: "Time to achieve remission determines time to be in remissio"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Time to achieve remission determines time to be in remission. | Schipper et al. Arthritis Research Therapy 2010 12 R97 http content 12 3 R97 RESEARCH ARTICLE Open Access Timelto achieve remission determines time to be in remission Lydia G Schipper 1 Jaap Fransen1 Alfons A den Breeder2 and Piet LCM Van Riel1 Abstract Introduction Though remission is currently a treatment goal in patients with rheumatoid arthritis RA the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the association between time-to-remission and sustainability of remission in a cohort of early RA patients treated according to daily practice. Methods For this study three-year follow-up data were used from the Nijmegen RA Inception Cohort of patients included between 1985 and 2005 N 753 . Patients were included upon diagnosis ACR criteria were systematically evaluated at three-monthly visits and treated according to daily practice. Remission was defined according to the Disease Activity Score DAS and the ACR remission criteria. Remission of at least 6 months duration was regarded as sustained remission. Predictors for time-to-remission were identified by Cox-regression analyses. The relation between time-to-remission and sustained remission was analyzed using longitudinal binary regression. Results N 398 52 patients achieved remission with a median time-to-remission of 12 months. Male gender younger age and low DAS at baseline were predictive to reach remission rapidly. There were n 142 36 patients experiencing sustained remission which was determined by a shorter time-to-remission only. The relationship between time-to-remission and sustained remission was described by a significant odds ratio to CI that was constant over the whole period 1985 to 2005. Results obtained with the ACR remission criteria were similar. Conclusions A shorter time-to-remission is related to .

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