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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Value of eight-amino-acid matches in predicting the allergenicity status of proteins: an empirical bioinformatic investigation. | Clinical and Molecular Allergy BioMed Central Research Value of eight-amino-acid matches in predicting the allergenicity status of proteins an empirical bioinformatic investigation Rod A Herman Ping Song and Arvind ThirumalaiswamySekhar Address Dow AgroSciences LLC 9330 Zionsville Road Indianapolis IN 46268 USA Email Rod A Herman - raherman@dow.com Ping Song - psong@dow.com Arvind ThirumalaiswamySekhar - AThirumalaiswamySekhar@dow.com Corresponding author Open Access Published 29 October 2009 Received I September 2009 Clinical and Molecular Allergy 2009 7 9 doi 10.1186 1476-7961-7-9 Accepted 29 October 2009 This article is available from http www.clinicalmolecularallergy.com content 7 I 9 2009 Herman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The use of biotechnological techniques to introduce novel proteins into food crops transgenic or GM crops has motivated investigation into the properties of proteins that favor their potential to elicit allergic reactions. As part of the allergenicity assessment bioinformatic approaches are used to compare the amino-acid sequence of candidate proteins with sequences in a database of known allergens to predict potential cross reactivity between novel food proteins and proteins to which people have become sensitized. Two criteria commonly used for these queries are searches over 80-amino-acid stretches for 35 identity and searches for 8-amino-acid contiguous matches. We investigated the added value provided by the 8-amino-acid criterion over that provided by the 35 -identity-over-80-amino-acid criterion by identifying allergens pairs that only met the former criterion but not the latter .
