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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua). | Comparative Hepatology BioMed Central Research Open Access Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A in juvenile Atlantic cod Gadus morhua Linda Hasselberg1 Bjorn E Grosvik2 Anders Goksoyr2 3 and Malin C Celander 1 Address department of Zoophysiology Goteborg University Box 463 SE 405 30 Goteborg Sweden department of Molecular Biology HIB University of Bergen N 5020 Bergen Norway and 3Biosense Laboratories AS N-5008 Bergen Norway Email Linda Hasselberg - linda.hasselberg@zool.gu.se Bjorn E Grosvik - bjorn.grosvik@mbi.uib.no Anders Goksoyr - anders@biosense.no Malin C Celander - malin.celander@zool.gu.se Corresponding author Published 08 February 2005 Received 29 September 2004 Accepted 08 February 2005 Comparative Hepatology 2005 4 2 doi 10.1186 1476-5926-4-2 This article is available from http www.comparative-hepatology.cOm content 4 1 2 2005 Hasselberg et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Xenoestrogens and antifungal azoles probably share a common route of metabolism through hepatic cytochrome P450 CYP enzymes. Chemical interactions with metabolic pathways may affect clearance of both xenobiotics and endobiotics. This study was carried out to identify possible chemical interactions by those substances on CYPIA and CYP3A in Atlantic cod liver. We investigated effects of two xenoestrogens nonylphenol and ethynylestradiol and of the model imidazole ketoconazole alone and in combination. Results Treatment with ketoconazole resulted in 60 increase in CYP1A-mediated ethoxyresorufin-O-deethylase EROD activity. Treatment with nonylphenol resulted in 40 reduction of CYP1A activity. Combined exposure to ketoconazole and nonylphenol resulted in 70 induction of
