TAILIEUCHUNG - Báo cáo y học: "Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liver"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liver. | Comparative Hepatology BioMed Central Review Open Access Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liver Hui Helen Wang 1 Hongming Qiu2 Ke Qi3 and F William Orr4 Address Department of Health Sciences Red River College and Department of Pathology Faculty of Medicine University of Manitoba Winnipeg Manitoba Canada 2Department of Pathology Health Sciences Center University of Manitoba Winnipeg Manitoba Canada 3Department of General Surgery Nanshan Hospital Shenzhen Guangdong China and 4Department of Pathology Faculty of Medicine University of Manitoba Winnipeg Manitoba Canada Email Hui Helen Wang - wangh0@ Hongming Qiu - qiuxx005@ Ke Qi - qike1792002@ F William Orr - worr@ Corresponding author Published 09 December 2005 Received 21 September 2005 Accepted 09 December 2005 Comparative Hepatology 2005 4 8 doi 86 1476-5926-4-8 r This article is available from http content 4 1 8 2005 Wang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Substantial recent experimental evidence has demonstrated the existence of reciprocal interactions between the microvascular bed of a specific organ and intravascular metastatic tumor cells through expression of adhesion molecules and nitric oxide release resulting in a significant impact upon metastatic outcomes. This review summarizes the current findings of adhesive and cytotoxic endothelial-tumor cell interactions in the liver the inducibility zonal distribution and sinusoidal structural influences on the hepatic endothelial regulatory functions and the effects of these functions on

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