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The objectives of the thesis: Identify Salmonella isolated from pork, beef, and chicken meat at the retail markets in Hanoi; determining antibiotic resistance characteristics of isolated Salmonella; analysis of related gene categories in multi-antibiotic resistant Salmonella. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY . . NGUYEN THANH VIET ANTIMICROBIAL RESISTANCE CHARACTERISTICS AND RELATED GENES OF MULTIDRUG-RESISTANT Salmonella Major Microbiology Code 9420107 SUMMARY OF BIOLOGY DOCTORAL THESIS Hanoi 2020 INTRODUCTION 1. The urgency of the thesis The burden of foodborne diseases is substantial. Each year foodborne diseases cause almost 1 in 10 people fall ill and 33 million of healthy life years are lost. Foodborne diseases can be severe especially for young children. Diarrhoeal diseases are the most common illnesses resulting from unsafe food 550 million people falling ill each year including 220 million children under the age of 5 years. Salmonella is 1 of the 4 key global causes of diarrhoeal diseases. The increasing rate of antibiotic resistance in Salmonella spp. poses a significant global concern and is a major threat to global health. Therefore it is necessary to isolate and identify antibiotic resistance characteristics of Salmonella from food. Studying the antibiotic resistance characteristics of Salmonella will provide important information for the prevention control of diseases as well as food contamination control and regulations on the use of antibiotics in treatment and animal husbandry in order to limit antibiotic resistance of bacteria. In Vietnam there has been no research on identifying related gene categories of multidrug-resistant Salmonella isolated from food using Next-generation sequencing. Studying the expression genome of Salmonella especially antibiotic resistance genes in multi antibiotic resistant Salmonella isolates provides insight into the molecular epidemiology of antibiotic resistance genes. More importantly it is possible to detect new mutations in antibiotic resistance genes that cause antibiotic resistance in Salmonella. In addition studying the expression genome could help to identify new gene groups that can cause .
