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7, 12-Dimethylbenz[a]anthracene (DMBA) is acting as immunosuppressor and it serves as a tumor initiator. Tumor promotion can be induced with treatments of 12-Otetradecanoylphorbol-13-acetate (TPA) in some models of two-stage carcinogenesis. This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible. The DMBA damages many internal organs including liver, by inducing the production of reactive oxygen species, DNA-adduct formation and affecting the activities of phase I, II, antioxidant and serum enzymes. The silibinin is a pharmacologically active constitute of Silybummarianum (L), with documented antioxidant activity. The aim of present attempt was to evaluate both histopathologically and biochemically whether silibinin is protective in DMBA induced liver damage. | Influence of sibinin on DMBA induced hepatotoxicity and free-radical damage in norwegian Rat Rattus norvegicus L .
