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At its simplest, biotechnology is technology based on biology. From that perspective, the use of biological processes is hardly noteworthy. We began growing crops and raising animals 10,000 years ago to provide a stable supply of food and clothing. We have used the biological processes of microorganisms for 6,000 years to make useful food products, such as bread and cheese, and to preserve dairy products. Crops? Cheese? That doesn’t sound very exciting. So why does biotechnology receive so much attention?. | guide to biotechnology 2008 hea th bioethics intellectual property research development food agriculture Bjg INDUSTRY ORGANIZATION industrial environmental biodefense bio.org The Guide to Biotechnology is compiled by the Biotechnology Industry Organization BIO Editors Roxanna Guilford-Blake Debbie Strickland Contributors BIO Staff table of Contents Biotechnology A Collection of Technologies 1 What Is Biotechnology .1 Cells and Biological Molecules.1 Biotechnology Industry Facts 2 Market Capitalization 1994-2006.3 U.S. Biotech Industry Statistics 1995-2006.3 U.S. Public Companies by Region 2006.4 Total Financing 1998-2007 in billions of U.S. dollars . 4 Biotech Industry Financing.5 Time Line 6 Biotechnology Policy Milestones.15 Technologies and Tools 18 Bioprocessing Technology . 18 Recombinant DNA Technology.18 Monoclonal Antibodies.19 Cloning. 20 Protein Engineering.20 Biosensors.21 Nanobiotechnology.21 Microarrays.22 From Biotechnology to Biology Using Biotech Tools to Understand Life 23 Research Applications of Biotechnology.23 Putting the Pieces Together Omics and Related Tools . 27 The Next Step Using New Knowledge to Develop Products.29 Health Care Applications 32 Diagnostics. 32 Therapeutics. 32 Personalized Medicine.35 Regenerative Medicine.36 Vaccines.37 Plant-Made Pharmaceuticals.37 Therapeutic Development Overview.38 Agricultural Production Applications 41 Crop Biotechnology. 41 Forest Biotechnology. 44 Animal Biotechnology . 45 Aquaculture.51 Global Area of Transgenic Crops 1995-2007 Industrial and Developing Countries million acres . 53 Global Area of Transgenic Crops in 2006 and 2007 by Country million acres .53 Agricultural Biotech Products on the Market 54 Food Biotechnology 60 Improving the Raw Materials.60 Food Processing . 61 Food Safety Testing.62 Industrial and Environmental Applications 63 Industrial Sustainability. 63 Biocatalysts . 64 Biofuel.64 Existing and Planned U.S. Cellulosic Ethanol Biorefineries.66 Green Plastics.67 Nanotechnology .