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The use of drugs and chemicals in aquaculture has been increased surprisingly due to the fact that it has been moving from low to high level of intensification. However, there is lack of information in snakehead fish farming. The study was conducted by interviewing 65 farmers in Dinh Quan, Trang Bom, and Bien Hoa, Dong Nai province to provide sufficient information on the use of chloramphenicol (CAP) and amoxicillin (AMX) in snakehead fish farming. Interview results showed that no employment of the 2 antibiotics in prevention of diseases. | Investigation on the use of chloramphenicol and amoxicillin in snakehead fish Channa maculata farming and analysis of those antibiotic residue in muscle samples