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Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-fve substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM1 and PIM2 inhibitors having pIC50 ranging from 5.55 to 9 µM and from 4.66 to 8.22 µM, respectively, using genetic function algorithm for variable selection and multiple linear regression analysis (MLR) to establish unambiguous and simple QSAR models based on topological molecular descriptors. | QSAR studies on PIM1 and PIM2 inhibitors using statistical methods A rustic strategy to screen for 5- 1H-indol-5-yl -1 3 4-thiadiazol analogues and predict their PIM inhibitory activity