TAILIEUCHUNG - QSAR and anti-depressant studies of some novel phenothiazine derivatives

Antidepressant, Phenothiazine, QSAR, Antidepressants are the drugs used to treat depression thereby elevates mood and modifies the behavior. The main aims in the development of new antidepressants were greater efficacy, absence of side effects, lack of toxicity in over dose and earlier onset of action. In this study, a series of novel substituted phenothiazine was synthesized and evaluated for antidepressant activity by using or forced swim test (FST). Our synthetic route started from substituted aniline which was reacted with cyclohexanone. The later compound with sulfur powder and iodine led to the formation of the title compounds. Total 12 phenothiazine derivatives, A1 to A12 were tested for antidepressant activity by using or forced swim test (FST). All the synthesized compounds were subjected to antidepressant activity study on Sprague-Dawley rats by despair swim test. Imipramine was used as standard control. The results showed that all the compounds showed antidepressant activity. Among them two compounds, A3 and A6 showed significant antidepressant activity comparing with standard control imipramine. | QSAR and anti-depressant studies of some novel phenothiazine derivatives

• Nông nghiệp
• Sprague dawley rats
• Novel phenothiazine derivatives
• Anti depressant studies
• Standard control imipramine
• Despair swim tes
• Angiotensin II
• Sympathetic nervous system
• Renin angiotensin system
• Vascular hemodynamics
• Anti TNF α receptor fusion protein
• Preclinical safety
• Anti tumor necrosis
• Factor alpha receptor fusion protein
• Silver nanoparticles
• Nanoparticles synthesized
• Cinnamomum cassia
• Biological systems
• BMC Pharmacology and Toxicology
• Cryptolepis sanguinolenta
• Metabolite identification
• Cryptolepine metabolites
• Sprague Dawley
• trình bày báo cáo
• tài liệu báo cáo khoa học
• nghiên cứu y học
• báo cáo y học
• kiến thức y học
• tài liệu báo cáo nghiên cứu khoa học
• cách trình bày báo cáo
• kiến thức bệnh thú y
• báo cáo bệnh thú y
• các nghiên về bệnh thú ý
• Cold exposure
• Adrenal medulla
• Tyrosine hydroxylase tyrosine hydroxylase mRNA
• Densitometric scanning
• Rosmarinic acid
• Sodium selenite
• Oxidative damage
• Sprague Dawley rat pups
• Therapeutic potential
• Anti cataract drugs
• BMC Chemistry
• In vivo metabolism
• Sprague–Dawley rats
• Phase II glucuronide conjugates
• Tyrosine kinases
• Lipid peroxidation
• Mammary carcinogenesis
• Idivallathi mezhugu on lipid peroxidation
• Effect of Idivallathi mezhugu
• Olive oil by oral gavage
• BMC Musculoskeletal Disorders
• Mitogen activated protein kinases
• Epidural fibrosis
• Mediate neuropathic pain
• Immunohistochemical analysis
• BMC Genomics
• Heat stress response
• Adrenal glands
• Heat shock protein
• Transcriptional regulation