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Hybrid materials based on tetraethyl orthosilicate (TEOS), hydroxypropyl cellulose (HPC), or hydroxypropyl methyl cellulose (HPMC) with silver nanoparticles were synthesized. They were analyzed and characterized using differential thermal analysis and thermogravimetry, atomic force microscopy, and static contact angle measurements. | Turkish Journal of Biology Turk J Biol (2016) 40: 1278-1288 © TÜBİTAK doi:10.3906/biy-1601-68 http://journals.tubitak.gov.tr/biology/ Research Article Cytotoxicity and antibiofilm activity of SiO2/cellulose derivative hybrid materials containing silver nanoparticles 1 2 3 1, Tsvetelina ANGELOVA , Nadezhda RANGELOVA , Veselina UZUNOVA , Nelly GEORGIEVA *, 3 3 3 4 Tonya ANDREEVA , Albena MOMCHILOVA , Rumiana TZONEVA , Rudolf MÜLLER 1 Department of Biotechnology, University of Chemical Technology and Metallurgy, Sofia, Bulgaria 2 Department of Fundamentals of Chemical Technology, University of Chemical Technology and Metallurgy, Sofia, Bulgaria 3 Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria 4 Institute of Technical Biocatalysis, Hamburg University of Technology, Hamburg, Germany Received: 25.01.2016 Accepted/Published Online: 19.04.2016 Final Version: 16.12.2016 Abstract: Hybrid materials based on tetraethyl orthosilicate (TEOS), hydroxypropyl cellulose (HPC), or hydroxypropyl methyl cellulose (HPMC) with silver nanoparticles were synthesized. They were analyzed and characterized using differential thermal analysis and thermogravimetry, atomic force microscopy, and static contact angle measurements. It was experimentally demonstrated that the silverdoped hybrid materials have pronounced antibacterial behavior by studying the reduction of Pseudomonas aeruginosa PAO1 biofilm formation on the tested materials. The results revealed biofilm reduction of 35.7% and 30% by SiO2/HPC/2.5% Ag and SiO2/HPMC/2.5% Ag hybrid materials, respectively, compared to the control. Cytotoxicity of examined materials and actin cytoskeleton organization of fibroblasts seeded on the materials was studied as a function of material properties as the type of surface functional groups and silver content. The obtained hybrid materials with low silver content proved efficient in tissue engineering applications since they showed good .
