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Chapter 11 - Cell communication. After reading this chapter, you should be able to answer the following questions: Why do you communicate? How do you communicate? How do you think cells communicate? Do you think bacteria can communicate? | Warm-Up Why do you communicate? How do you communicate? How do you think cells communicate? Do you think bacteria can communicate? Explain. Warm-Up Compare the structure & function of these receptor proteins: GPCR, tyrosine kinase and ligand-gated ion channels. What is a second messenger? What are some examples of these molecules? What are the possible responses to signal transduction in a cell? Cell Communication CHAPTER 11 What you should know: The 3 stages of cell communication: reception, transduction, and response. How G-protein-coupled receptors receive signals and start transduction. How receptor tyrosine kinase receive cell signals and start transduction. How a cell signal is amplified by a phosphorylation cascade. How a cell response in the nucleus turns on genes while in the cytoplasm it activates enzymes. What apoptosis means and why it is important to normal functioning of multicellular organisms. Do bacteria communicate? Bonnie Bassler on How Bacteria “Talk” Video Questions: Why are scientists studying how bacteria (and not just human cells) communicate? What is quorum sensing? Describe how Vibrio fischeri use quorum sensing in squid. According to Bonnie Bassler (Princeton University), what are scientists hoping to use as the next class of antibiotics? Cell Signaling Animal cells communicate by: Direct contact (gap junctions) Secreting local regulators (growth factors, neurotransmitters) Long distance (hormones) 3 Stages of Cell Signaling: Reception: Detection of a signal molecule (ligand) coming from outside the cell Transduction: Convert signal to a form that can bring about a cellular response Response: Cellular response to the signal molecule Reception Transduction Response 1. Reception Binding between signal molecule (ligand) + receptor is highly specific. Types of Receptors: Plasma membrane receptor water-soluble ligands Intracellular receptors (cytoplasm, nucleus) hydrophobic or small ligands Eg. testosterone or nitric oxide (NO) Ligand binds to | Warm-Up Why do you communicate? How do you communicate? How do you think cells communicate? Do you think bacteria can communicate? Explain. Warm-Up Compare the structure & function of these receptor proteins: GPCR, tyrosine kinase and ligand-gated ion channels. What is a second messenger? What are some examples of these molecules? What are the possible responses to signal transduction in a cell? Cell Communication CHAPTER 11 What you should know: The 3 stages of cell communication: reception, transduction, and response. How G-protein-coupled receptors receive signals and start transduction. How receptor tyrosine kinase receive cell signals and start transduction. How a cell signal is amplified by a phosphorylation cascade. How a cell response in the nucleus turns on genes while in the cytoplasm it activates enzymes. What apoptosis means and why it is important to normal functioning of multicellular organisms. Do bacteria communicate? Bonnie Bassler on How Bacteria “Talk” Video .
