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Bergenin, isolated for the first time from Ficus glomerata bark, was identified by the spectroscopic methods, including 2D-NMR spectra. | Journal of Chemistry Vol. 42 2 P. 250 - 252 2004 BERGENIN ISOLATED FROM FICUS GLOMERATA BARK Received 1-7-2003 NGUYEN THE DUNG1 PHAM DINH TY1 W. C. TAYLOR2 VU DINH HOANG3 institute of Natural Products Chemistry Vietnamese Academy of Science and Technology 2School of Chemistry University of Sydney Australia institute of Chemistry Vietnamese Academy of Science and Technology SUMMARY Bergenin isolated for the first time from Ficus glomerata bark was identified by the spectroscopic methods including 2D-NMR spectra. I - INTRODUCTION The bark of Ficus glomerata Roxb. is a popular drug of Vietnam having activity against boils. As reported in 1 six components were isolated from the bark of this plant - F1 F2 F3 F4 F6 F7 and component F6 was identified as bergenin. That was the first time bergenin had been isolated from Ficus glomerata bark although it has been reported to be present in the latex 2 . Bergenin has been reported to show weak anti-HIV activity 3 and anti-arrhythmic activity 4 . This paper presents spectral data of bergenin complementary to those published in previous papers 3 5 - 8 the Nuclear Magnetic Resonance NMR spectral data table 1 being especially informative of the structure. II - RESULTS AND DISCUSSION The Infrared IR spectrum of F6 showed absorption bands at 3425 - 3200 cm-1 from OH groups with intermolecular hydrogen bonds and a strong carbonyl band at 1703 cm-1. The NMR spectral data are shown in table 1. The 1H was assigned on the basis of COSY spectrum and then 13C-NMR assignments were made from DEPT HMQC and HMBC spectra. The 2J and 3J correlations in the HMBC spectrum have given good support for the structure of bergenin. The spectral data of F7 are equivalent to those of F6. MS of both F6 and F7 showed a molecular ion peak M at m z 328 19 and the base peak at m z 208 100 . According to 7 it is concluded that F6 is the crystalline hydrate form of bergenin and F7 - its anhydrous crystalline form. H CH3 H 2 fnyiO H . Unlkj UUoH L T10b4. OH H 0 -
