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There are at least three well-defined signalling cascades engaged directly in the physiological regulation of cardiac circulatory function: theb1-adrenoceptors that control the cardiac contractile apparatus,the renin-angiotensin-aldo-sterone system involved in regulating bloodpressure and the natriuretic peptides contributing at least to the factors determining circulating volume. | Eur. J. Biochem. 269 4713- 7730 2002 FEBS 2002 doi 10.1046 j.1432-1033.2002.03181.x REVIEW ARTICLE Receptor crosstalk Implications for cardiovascular function disease and therapy Nduna Dzimiri Cardiovascular Pharmacology Laboratory Biological and Medical Research Department King Faisal Specialist Hospital Research Centre Riyadh Saudi Arabia There are at least three well-defined signalling cascades engaged directly in the physiological regulation of cardiac circulatory function the b1-adrenoceptors that control the cardiac contractile apparatus the innin-angiolensin-aldo-sterone system involved in regulating blood pressure and the natriuretic peptides contributing at least to the factors determining circulating volume. Apart from these pathways other cardiac receptor systems aitiici-lkilly the a1-adreno-ceptors adenosine endothelin and opioid receptors whose physiological role may not be immediately evident are also important with respect to regulating cardiovascular function especially in disease. These and the majority of other cardiovascular receptors identified to date belong to the guanine nucleotide binding G protein-coupled receptor families that mediate signalling by coupling primarily to three G proteins hhe slimukilory Gs íhhibitoty Gj and Gq 11 proteins to stimulate the adenylate cyclases and phospholipases activating a small but diverse subset off elhecloss and ion channels. These receptor pathways are engaged in crosstalk utilizing second messengers and protein kinases as checkpoints and hubs for diverting converging 8 nnd directing the G protein-mediated messages resulting in different signalling products. Besides the heart ì tsef is endowed with the means to harmonize these signalling mechanisms and to fend off potentially fatal consequences of functional loss of the essential signalling pathways via compensatory reserve pathways co by i nd Iicing some adaptive mechanisms to be turned on if and when required. This receptor crosstalk constitutes the .
