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Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma

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Volunteers Provide Substantial Benefits to Charities and Congregations. In 2003, approximately 63.8 million Americans volunteered in or through an organization, while thousands of charities and congregational social service programs engaged and managed these volunteers. Charities and congregations report that these volunteers are important to their operations, and that volunteers do a good job in providing services. At least six in ten charities indicate that their volunteers provide substantial cost savings and greatly increase the quality of services or programs provided, public support for their programs, and the level of services they can provide. Only six percent of charities and congregational social service outreach programs report that absenteeism, unreliability, or poor work habits are a. | National Heart Lung and Blood Institute National Asthma Education and Prevention Program Expert Panel Report 3 Guidelines for the Diagnosis and Management of Asthma Full Report 2007 U.S. Department of Health and Human Services National Institutes of Health National Heart Lung and Blood Institute August 28 2007 Contents CONTENTS Acknowledgements and Financial Disclosures.xi Acronyms and Abbreviations.xix Preface.xxii Section 1 Introduction.1 Overall Methods Used To Develop This Report.2 Background. 2 Systematic Evidence Review Overview.3 Inclusion Exclusion Criteria.3 Search Strategies .3 Literature Review Process.3 Preparation of Evidence Tables.6 Ranking the Evidence.7 Panel Discussion.8 Report Preparation.8 References.9 Section 2 Definition Pathophysiology and Pathogenesis of Asthma and Natural History of Asthma.11 Key Points Definition Pathophysiology and Pathogenesis of Asthma and Natural History of Asthma.11 Key Differences From 1997 and 2002 Expert Panel Reports.12 Introduction.12 Definition of Asthma.12 Pathophysiology and Pathogenesis of Asthma.14 Pathophysiologic Mechanisms in the Development of Airway Inflammation.16 Inflammatory Cells. 16 Inflammatory Mediators.18 Immunoglobulin E. 19 Implications of Inflammation for Therapy.19 Pathogenesis .20 Host Factors.20 Environmental Factors.22 Natural History of Asthma.23 Natural History of Persistent Asthma.24 Children.24 Adults.25 Summary.27 Effect of Interventions on Natural History of Asthma.27 Implications of Current Information About Pathophysiology and Pathogenesis and Natural History for Asthma Management.28 References.28 i Contents August 28 2007 Section 3 The Four Components of Asthma Management.35 Introduction.35 Section 3 Component 1 Measures of Asthma Assessment and Monitoring.36 Introduction.36 Overview of Assessing and Monitoring Asthma Severity Control and Responsiveness in Managing Asthma.36 Key Points Overview of Measures of Asthma Assessment and Monitoring.36 Key Differences From 1997 and 2002

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