Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
(BQ) Part 2 book "Essentials of pharmacology for anesthesia, pain medicine and critical care" presents the following contents: Histamine modulators, central nervous system stimulants, antiepileptic agents, chemotherapeutic agents, minerals and electrolytes, psychopharmacologic agents and psychiatric drug considerations,. | Chapter 22 Histamine Modulators Michael Yarborough and Judy G. Johnson Contents Introduction. 365 Drug Class and Mechanism of Action. 366 Indications and Clinical Pearls. 367 Drug Interactions Side Effects Black Box Warnings. 374 Cardiac Effects. 374 CNS Effects. 375 Summary . 377 Chemical Structures . 377 References. 378 Introduction Discovery of certain chemicals to counteract the effects of histamine occurred in the early twentieth century. The development of a drug that would alleviate allergic reactions such as itchy watery eyes and a runny nose from a cold or hay fever had an astronomical effect on the medical community. By the 1950s antihistamines were being mass-produced in the USA and prescribed extensively as the drug of choice for those suffering from allergies. The public perceived antihistamines as the wonder drug and with the misconception that it was a cure all to the common cold. Eventually scientist began to discover additional indications for the use of antihistamines. These compounds continue to be one of the most universal drugs lining the shelves of local pharmacies. However the plethora of roles that antihistamines play in the treatment of the human condition is much more extensive including suppression of allergy symptoms sedative agents and antiemetic actions to name a few. M. Yarborough MD Department of Anesthesiology Tulane Medical Center New Orleans LA USA e-mail myarboro@tulane.edu J.G. Johnson MD Department of Anesthesiology Louisiana State University New Orleans LA USA A.D. Kaye et al. eds. Essentials of Pharmacology for Anesthesia 365 Pain Medicine and Critical Care Doi 10.1007 978-1-4614-8948-1_22 Springer Science Business Media New York 2015 366 M. Yarborough and J.G. Johnson Drug Class and Mechanism of Action Histamine is involved in local immune responses as well as regulation of physiologic functions in the gut. It can also act as a neurotransmitter. Histamine is made and released by different cells i.e. basophils mast cells .
