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Mifepristone and a prostaglandin have been used successfully to terminate pregnancy in Europe and China. We report the results of a large U.S. study of mifepristone and misoprostol in women with pregnancies of up to nine weeks’ duration. | ResearchGate See discussions stats and author profiles for this publication at http www.researchgate.net publication 13717030 Early pregnancy termination with mifepristone and misoprostol in the United States ARTICLE in NEW ENGLAND JOURNAL OF MEDICINE MAY 1998 Impact Factor 54.42 DOI 10.1056 NEJM199804303381801 Source PubMed CITATIONS DOWNLOADS VIEWS 282 259 129 4AUTHORS INCLUDING Irving M Spitz 184 PUBLICATIONS 3 613 CITATIONS SEE PROFILE Available from Irving M Spitz Retrieved on 24 July 2015 The New England Journal of Medicine Copyright 1998 by the Massachusetts Medical Society VOLUME 338 April 30 1998 NUMBER 18 EARLY PREGNANCY TERMINATION WITH MIFEPRISTONE AND MISOPROSTOL IN THE UNITED STATES Irving M. Spitz M.D. D.Sc. C. Wayne Bardin M.D. Lauri Benton M.D. AND Ann Robbins Ph.D. Abstract Background Mifepristone and a prostaglandin have been used successfully to terminate pregnancy in Europe and China. We report the results of a large U.S. study of mifepristone and misoprostol in women with pregnancies of up to nine weeks duration. Methods We administered 600 mg of mifepristone and then 400 mg of misoprostol two days later to 2121 women seeking termination of their pregnancies at 17 centers. The women were observed for four hours after the administration of misoprostol and returned on day 15 for final assessment. Results Two thousand fifteen women completed the final assessment. Among them pregnancy was terminated in 762 of the 827 women pregnant for 49 days 92 percent 563 of the 678 wiomen pregnant for 50 to 56 days 83 percent and 395 of the 510 women pregnant for 57 to 63 days 77 percent P 0.001 . Termination occurred within 4 hours after the administration of misoprostol in 49 percent of the women and within 24 hours in 75 percent. Failures defined as cases requiring surgical intervention for medical reasons or because the patient requested it the abortion was incomplete or the pregnancy was ongoing increased with increasing duration of pregnancy. The largest
