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Ammonium trichloro(dioxoethylene-o,o¢)tellurate (AS101) is an organotel-lurium compound with pleiotropic functions that has been associated with antitumoral, immunomodulatory and antineurodegenerative activities. Tel-lurium compounds with a +4 oxidation state, such as AS101, react uniquely with thiols, forming disulfide molecules. | ỊFEBS Journal The organotellurium compound ammonium trichloro dioxoethylene-o o tellurate reacts with homocysteine to form homocystine and decreases homocysteine levels in hyperhomocysteinemic mice Fi an Oln I n 1 a K aw rìilốcKÝíii n 1 A In n a rmiilv1 I I ana I airla1 ahi Eroi1 Pon-Ami nla2 c I Lal I wi Ui I I a Iiav Lz I ixsiLcii I MIUII vaimuiy riayai uaiua JaUi lie Del IHI HI ucid Lydia Varshavsky1 Asher Ofir3 Esthy Levy3 Michael Albeck3 and Benjamin Sredni1 1 CAIR Institute The Safdie AIDS and Immunology Research Center Bar-Ilan University Ramat-Gan Israel 2 Institute of ChemicalPathology Chaim Sheba MedicalCenter Tel-Hashomer Israel 3 Department of Chemistry Faculty of Exact Sciences Bar-Ilan University Ramat-Gan Israel Keywords AS101 homocysteine hyperhomocysteinemia organotellurium tellurium Correspondence B. Sredni Safdie Institute for AIDS and Immunology Research The Mina Everard Goodman Faculty of Life Sciences Bar-Ilan University Ramat-Gan 52900 Israel Fax 972 36356041 Tel 972 35318250 E-mail srednib@mail.biu.ac.il srednib@gmail.com These authors contributed equally to this work Received 21 November 2006 revised 4 April2007 accepted 24 April 2007 Ammonium trichloro dioxoethylene-o o tellurate AS101 is an organotel-lurium compound with pleiotropic functions that has been associated with antitumoral immunomodulatory and antineurodegenerative activities. Tellurium compounds with a 4 oxidation state such as AS101 react uniquely with thiols forming disulfide molecules. In light of this we tested whether AS101 can react with the amino acid homocysteine both in vitro and in vivo. AS101 conferred protection against homocysteine-induced apoptosis of HL-60 cells. The protective mechanism of AS101 against homocysteine toxicity was directly mediated by its chemical reactivity whereby AS101 reacted with homocysteine to form homocystine the less toxic disulfide form of homocysteine. Moreover AS101 was shown here to reduce the levels of total homocysteine in an in .
