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An investigation of cognitive 'branching' processes in major depression | BMC Psychiatry BioMed Central Research article Open Access An investigation of cognitive branching processes in major depression Nicholas D Walsh 1 Marc L Seal2 Steven CR Williams1 and Mitul A Mehta1 Address 1Centre for Neuroimaging Sciences Institute of Psychiatry King s College London UK and 2Melbourne Neuropsychiatry Centre University of Melbourne Victoria Australia Email Nicholas D Walsh - nickwalsh100@gmail.com Marc L Seal - mseal@unimelb.edu.au Steven CR Williams - s.williams@iop.kck.ac.uk Mitul A Mehta - m.mehta@iop.kcl.ac.uk Corresponding author Published 10 November 2009 Received 5 January 2009 Accepted 10 November 2009 BMC Psychiatry 2009 9 69 doi l0.ll86 l47l-244X-9-69 p This article is available from http www.biomedcentral.com l47l-244X 9 69 2009 Walsh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Patients with depression demonstrate cognitive impairment on a wide range of cognitive tasks particularly putative tasks of frontal lobe function. Recent models of frontal lobe function have argued that the frontal pole region is involved in cognitive branching a process requiring holding in mind one goal while performing sub-goal processes. Evidence for this model comes from functional neuroimaging and frontal-pole lesion patients. We have utilised these new concepts to investigate the possibility that patients with depression are impaired at cognitive branching . Methods l l non-medicated patients with major depression were compared to l l matched controls in a behavioural study on a task of cognitive branching . In the version employed here we recorded participant s performance as they learnt to perform the task. This involved participants completing a control condition followed by a .
