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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Ventilatory abnormalities in sepsis. | Available online http ccforum.eom content 13 1 202 Review Bench-to-bedside review Ventilatory abnormalities in sepsis Sheldon Magder McGill University Health Centre Division of Critical Care Department of Medicine Pine Avenue W Montreal Quebec H3A 1A1 Canada Corresponding author Sheldon Magder Sheldon.magder@mcgill.ca Published 15 January 2009 This article is online at http ccforum.com content 13 1 202 2009 BioMed Central Ltd Critical Care 2009 13 202 doi 10.1186 cc7116 Abstract In septic patients increased central drive and increased metabolic demands combine to increase energy demands on the ventilatory muscles. This occurs at a time when energy supplies are limited and energy production hindered and it leads to an energy supplydemand imbalance and often ventilatory failure. Problems related to contractile function of the ventilatory muscles also contribute especially when the clinical course is prolonged. The increased ventilatory activity increases interactions between the ventilatory and cardiovascular systems and when ventilatory muscles fail and mechanical ventilatory support is required a new set of problems emerges. In this review I discuss factors related to ventilatory muscle failure giving emphasis to mechanical and supply demand aspects. I also review the implications of changes in ventilatory patterns for heart-lung interactions. Introduction Abnormalities of ventilation are an important part of the septic syndrome 1 and an understanding of the pathophysiology of these disorders is essential in the management of septic patients. Disorders of ventilation can be broadly classified as abnormalities related to the following ventilatory drive function of the ventilatory pump which is dependent upon the supply of energy the demand for energy and the intrinsic function of the muscle and abnormalities related to the interaction of the ventilatory and cardiovascular systems heartlung interactions . In this review I discuss each of these giving emphasis to .