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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Hydrogen sulfide – the third gaseous transmitter: applications for critical care. | Available online http ccforum.eom content 13 3 213 Review Bench-to-bedside review Hydrogen sulfide - the third gaseous transmitter applications for critical care Florian Wagner1 Pierre Asfar2 3 Enrico Calzia1 Peter Radermacher1 and Csaba Szabo4 5 1Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Klinik fur Anastehsiologie Universitatsklinikum Parkstrasse 11 89073 Ulm Germany 2Laboratoire HIFIH UPRES EA 3859 IFR 132 Université d Angers 49933 Angers France 3Département de Réanimation Médicale et de Médecine Hyperbare Centre Hospitalo-Universitaire 49933 Angers France 4Ikaria Seattle WA 98102 USA 5Department of Anesthesiology The University of Texas Medical Branch 610 Texas Avenue Galveston TX 77555-0833 USA Corresponding author Peter Radermacher peter.radermacher@uni-ulm.de Published 3 June 2009 This article is online at http ccforum.com content 13 3 213 2009 BioMed Central Ltd Critical Care 2009 13 213 doi 10.1186 cc7700 Abstract Hydrogen sulfide H2S a gas with the characteristic odor of rotten eggs is known for its toxicity and as an environmental hazard inhibition of mitochondrial respiration resulting from blockade of cytochrome c oxidase being the main toxic mechanism. Recently however H2S has been recognized as a signaling molecule of the cardiovascular inflammatory and nervous systems and therefore alongside nitric oxide and carbon monoxide is referred to as the third endogenous gaseous transmitter. Inhalation of gaseous H2S as well as administration of inhibitors of its endogenous production and compounds that donate H2S have been studied in various models of shock. Based on the concept that multiorgan failure secondary to shock inflammation and sepsis may represent an adaptive hypometabolic reponse to preserve ATP homoeostasis particular interest has focused on the induction of a hibernation-like suspended animation with H2S. It must be underscored that currently only a limited number of data are available from clinically relevant large
