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Báo cáo y học: " Albumin dialysis improves hepatic encephalopathy and decreases circulating phenolic aromatic amino acids in patients with alcoholic hepatitis and severe liver failure"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Albumin dialysis improves hepatic encephalopathy and decreases circulating phenolic aromatic amino acids in patients with alcoholic hepatitis and severe liver failure. | Available online http ccforum.eom content 13 1 R8 Research Albumin dialysis improves hepatic encephalopathy and decreases circulating phenolic aromatic amino acids in patients with alcoholic hepatitis and severe liver failure Albert Parés Ramón Deulofeu Laura Cisneros Angels Escorsell Joan Manuel Salmerón Joan Caballería and Antoni Mas Liver Unit Digestive Diseases Institute. Hospital Clinic Centro de Investigaciones Biomédicas en Red de Enfermedades Hepáticas y Digestivas CIBERehd Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS C . Villarroel 170 Barcelona 08036 Spain Corresponding author Albert Parés pares@ub.edu Received 28 Nov 2008 Revisions requested 8 Jan 2009 Revisions received 22 Jan 2009 Accepted 28 Jan 2009 Published 28 Jan 2009 Critical Care 2009 13 R8 doi 10.1186 cc7697 This article is online at http ccforum.com content 13 1 R8 2009 Parés et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The aim of this study was to assess the effects of albumin dialysis on hepatic encephalopathy and circulating levels of amino acids in severe alcoholic hepatitis. Methods The study was carried out in nine patients with severe alcoholic hepatitis and four with primary biliary cirrhosis treated with the molecular adsorbent recirculating system. Besides standard liver function tests circulating levels of ammonia total branched chain and aromatic amino acids the presence and severity of hepatic encephalopathy and number connection test were measured before and after each treatment. Results There were eight episodes of encephalopathy in patients with alcoholic hepatitis. Albumin dialysis was associated with significant improvement in encephalopathy p 0.02 and a decrease in total