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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep. | Available online http ccforum.eom content 1 2 4 R104 Research Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep Kristine Waerhaug1 Vladimir N Kuklin1 Mikhail Y Kirov1 2 Mikhail A Sovershaev3 Bodil Langbakk4 Ole C Ingebretsen5 Kirsti Ytrehus6 and Lars J Bjertnaes1 Department of Anesthesiology Institute of Clinical Medicine Faculty of Medicine University of Tromso Norway 2Department of Anesthesiology Northern State Medical University Arkhangelsk Russian Federation 3Department of Biochemistry Institute of Medical Biology Faculty of Medicine University of Tromso Norway 4Department of Medical Biochemistry University Hospital of North Norway Tromso Norway 5Department of Medical Biochemistry Institute of Medical Biology Faculty of Medicine University of Tromso Norway 6Department of Medical Physiology Institute of Medical Biology Faculty of Medicine University of Tromso Norway Corresponding author Lars J Bjertnaes lars.bjertnaes@fagmed.uit.no Received 19 Jun 2008 Revisions requested 19 Jul 2008 Revisions received 1 Aug 2008 Accepted 15 Aug 2008 Published 15 Aug 2008 Critical Care 2008 12 R104 doi 10.1186 cc6985 This article is online at http ccforum.com content 12 4 R1 04 2008 Waerhaug et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Acute lung injury often complicates severe sepsis. In Gram-negative sepsis bacterial endotoxin activates both coagulation and inflammation. Enhanced lung vascular pressures and permeability increased extravascular lung water content and deteriorated gas exchange characterize ovine endotoxin-induced lung injury a frequently used model of acute lung injury. Recombinant human activated protein C rhAPC with its .