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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate? | Available online http ccforum.eom content 12 4 423 Letter Acute kidney injury time to shift from creatinine to the estimated glomerular filtration rate Giuseppe Lippi and Gian Cesare Guidi Sezione di Chimica Clinica Dipartimento di Scienze Morfologico-Biomediche Università degli Studi di Verona Ospedale Policlinico G.B. Rossi Piazzale Scuro 10 37134 Verona Italy Corresponding author Prof Giuseppe Lippi ulippi@tin.it Published 25 July 2008 This article is online at http ccforum.com content 12 4 423 2008 BioMed Central Ltd Critical Care 2008 12 423 doi 10.1186 cc6936 See related research by Mehta et al. http ccforum.com content 11 2 R31 Acute kidney injury AKI is a complex disorder for which currently there is no accepted definition. Although several groups are working on developing and validating biomarkers of kidney injury and the glomerular filtration rate GFR the proposed diagnostic criteria from the Acute Kidney Injury Network are based on an absolute increase in serum creatinine 0.3 mg dl 26.4 ựmol l a percentage increase in serum creatinine 50 1.5-fold from baseline or a reduction in urine output documented oliguria 0.5 ml kg per hour for more than 6 hours 1 . A recent report from the Laboratory Working Group of the National Kidney Disease Education Program however recommends that serum creatinine alone should not be used to assess the GFR or to detect the presence of kidney disease because it is affected by the GFR and by factors independent of the GFR including age sex race body size diet certain drugs and laboratory analytical methods 2 . Rather the Working Group suggests implementing the estimated GFR using the Modification of Diet in Renal Disease MDRD study 2 . In analogy with chronic kidney disease implementation of the MDRD equation would probably grant more clinically useful information to assess AKI. Authors response Ravindra L Mehta John A Kellum Sudhir V Shah Bruce A Molitoris Claudio Ronco David G Warnock Adeera Levin and Michael Joannidis Lippi .
