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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Angiopoietin signalling in critical illness – a future target? | Available online http ccforum.eom content 13 2 207 Review Bench-to-bedside review Angiopoietin signalling in critical illness - a future target Matijs van Meurs1 2 Philipp Kumpers3 Jack JM Ligtenberg1 John HJM Meertens1 Grietje Molema2 and Jan G Zijlstra1 1 Department of Critical Care University Medical Center Groningen University of Groningen 9700RB Groningen The Netherlands 2Department of Pathology and Medical Biology Medical Biology Section University Medical Center Groningen University of Groningen HPC EA11 PO Box 30.001 9700 RB Groningen The Netherlands 3Department of Nephrology Hypertension Hanover Medical School Carl-Neuberg-strasse 1 Hannover D 30171 Germany Corresponding author Jan G Zijlstra j.g.zijlstra@int.umcg.nl Published 9 March 2009 This article is online at http ccforum.com content 13 2 207 2009 BioMed Central Ltd Critical Care 2009 13 207 doi 10.1186 cc7153 Abstract Multiple organ dysfunction syndrome MODS occurs in response to major insults such as sepsis severe haemorrhage trauma major surgery and pancreatitis. The mortality rate is high despite intensive supportive care. The pathophysiological mechanism underlying MODS are not entirely clear although several have been proposed. Overwhelming inflammation immunoparesis occult oxygen debt and other mechanisms have been investigated and - despite many unanswered questions - therapies targeting these mechanisms have been developed. Unfortunately only a few interventions usually those targeting multiple mechanisms at the same time have appeared to be beneficial. We clearly need to understand better the mechanisms that underlie MODS. The endothelium certainly plays an active role in MODS. It functions at the intersection of several systems including inflammation coagulation haemodynamics fluid and electrolyte balance and cell migration. An important regulator of these systems is the angiopoietin Tie2 signalling system. In this review we describe this signalling system giving special attention to what
