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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study | Paradise et al. BMC Psychiatry 2011 11 108 http www.biomedcentral.com 1471-244X 11 108 BMC Psychiatry RESEARCH ARTICLE Open Access Subjective memory complaints vascular risk factors and psychological distress in the middle-aged a cross-sectional study Matt B Paradise1 Nick S Glozier1 Sharon L Naismith1 Tracey A Davenport2 and Ian B Hickle1 Abstract Background Subjective memory complaints SMC are common but their significance is still unclear. It has been suggested they are a precursor of mild cognitive impairment MCI or dementia and an early indicator of cognitive decline. Vascular risk factors have an important role in the development of dementia and possibly MCI. We therefore aimed to test the hypothesis that vascular risk factors were associated with SMC independent of psychological distress in a middle-aged community-dwelling population. Methods A cross-sectional analysis of baseline data from the 45 and Up Study was performed. This is a cohort study of people living in New South Wales Australia and we explored the sample of 45 532 participants aged between 45 and 64 years. SMC were defined as fair or poor on a self-reported five-point Likert scale of memory function. Vascular risk factors of obesity diabetes hypertension hypercholesterolemia and smoking were identified by self-report. Psychological distress was measured by the Kessler Psychological Distress Scale. We tested the model generated from a randomly selected exploratory sample n 22 766 with a confirmatory sample of equal size. Results 5 479 45 532 12 of respondents reported SMC. Using multivariate logistic regression only two vascular risk factors smoking OR 1.18 95 CI 1.03 - 1.35 and hypercholesterolaemia OR 1.19 95 CI 1.04 - 1.36 showed a small independent association with SMC. In contrast psychological distress was strongly associated with SMC. Those with the highest levels of psychological distress were 7.00 95 CI 5.41 - 9.07 times more likely to have SMC than the non-distressed. The confirmatory
