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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome. | Ishiura et al. Cough 2010 6 7 http www.coughjournal.eom content 6 1 7 RESEARCH w Cough Open Access Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome 1 2 1 2 2 Yoshihisa Ishiura Masaki Fujimura Hiroki Yamamoto Noriyuki Ohkura Shigeharu Myou Abstract Background Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase COX -2 one of the inducible isoforms of COX is a key element in the pathophysiological process of a number of inflammatory disorders. However little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation. Methods The effect of etodolac a potent COX-2 inhibitor on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized placebo-controlled cross-over study. Capsaicin cough threshold defined as the lowest concentration of capsaicin eliciting five or more coughs was measured as an index of airway cough reflex sensitivity. Results The cough threshold was significantly p 0.03 increased after two-week treatment with etodolac 200 mg twice a day orally compared with placebo 37.5 GSEM 1.3 vs. 27.2 GSEM 1.3 gM . Conclusions These findings indicate that COX-2 may be a possible modulator augmenting airway cough reflex sensitivity in patients with sinobronchial syndrome. Background Chronic productive cough is one of the most common symptoms in patients with sinobronchial syndrome a common chronic bronchial disorder which is defined as a coexisting chronic sinusitis and nonspecific chronic neutrophilic inflammation of the lower airways presenting with expectoration e.g. chronic bronchitis diffuse bronchiectasis and diffuse panbronchiolitis 1 . Although clinical efficacy for low-dose and long-term erythromycin therapy EM therapy has .
