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Báo cáo y học: " A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytes | Retrovirology BioMed Central Research Open Access A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1 TRF2 and Poti in resting activated HTLV-1-transformed and Tax-expressing human T lymphocytes Emmanuelle Escoffied1 Amélie Rezza11 Aude Roborel de Climens2 Aurélie Belleville2 Louis Gazzolo1 Eric Gilson2 and Madeleine Duc Dodon 1 Address 1Virologie Humaine INSERM-U412 Ecole Normale Supérieure de Lyon IFR 128 BioSciences Lyon-Gerland 46 Allée d Italie 69364 Lyon Cedex 07 France and 2Laboratoire de Biologie Moléculaire de la Cellule CNRS UMR 5161 Ecole Normale Supérieure de Lyon IFR 128 BioSciences Lyon-Gerland 46 allée d Italie 69364 Lyon Cedex 07 France Email Emmanuelle Escoffier - emmanuelle.escoffier@wanadoo.fr Amélie Rezza - arezza@ens-lyon.fr Aude Roborel de Climens - aroborel@ens-lyon.fr Aurélie Belleville - abellevi@ens-lyon.fr Louis Gazzolo - louis.gazzolo@ens-lyon.fr Eric Gilson - eric.gilson@ens-lyon.fr Madeleine Duc Dodon - madeleine.duc.dodon@ens-lyon.fr Corresponding author tEqual contributors Published 15 December 2005 Received 05 October 2005 Accepted 15 December 2005 Retrovirology 2005 2 77 doi 10.1186 1742-4690-2-77 H This article is available from http www.retrovirology.cOm content 2 1 77 2005 Escoffier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The functional state of human telomeres is controlled by telomerase and by a protein complex named shelterin including the telomeric DNA-binding proteins TRF1 TRF2 and Pot1 involved in telomere capping functions. The expression of hTERT encoding the catalytic subunit of telomerase plays a crucial role in the control of lymphocyte proliferation by maintaining telomere homeostasis. It has been .