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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line | Retrovirology BioMed Central Short report Open Access PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line Chikako Tsubata1 2 Masaya Higuchi1 Masahiko Takahashi1 Masayasu Oie1 Yuetsu Tanaka3 Fumitake Gejyo2 and Masahiro Fujii 1 Address 1Division of Virology Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-Dori Niigata 951-8510 Japan 2Division of Clinical Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-Dori Niigata 951-8510 Japan and 3Department of Infectious Disease and Immunology Okinawa-Asia Research Center of Medical Science Faculty of Medicine University of the Ryukyus Okinawa Japan Email Chikako Tsubata - chikakot@med.niigata-u.ac.jp Masaya Higuchi - mhiguchi@med.niigata-u.ac.jp Masahiko Takahashi - masahiko@med.niigata-u.ac.jp Masayasu Oie - moie@med.niigata-u.ac.jp Yuetsu Tanaka - yuetsu@ma.kcom.ne.jp Fumitake Gejyo - gejyo@med.niigata-u.ac.jp Masahiro Fujii - fujiimas@med.niigata-u.ac.jp Corresponding author Published 23 July 2005 Received 20 July 2005 Retrovirology 2005 2 46 doi 10.1186 1742-4690-2-46 Accepted 23 July 2005 This article is available from http www.retrovirology.cOm content 2 1 46 2005 Tsubata et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human T-cell leukemia virus type 1 HTLV-1 is the etiologic agent of adult T-cell leukemia ATL whereas HTLV type 2 HTLV-2 is not associated with ATL or any other leukemia. HTLV-1 encodes the transforming gene taxi whose expression in an interleukin IL -2-dependent T-cell line CTLL-2 induces IL-2-independent growth. Results In this study we
