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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa. | Retrovirology BioMed Central Short report Open Access Discovery of a new human T-cell lymphotropic virus HTLV-3 in Central Africa Sara Calattini 1 Sébastien Alain Chevalier 1 Renan Duprez1 Sylviane Bassot1 Alain Froment2 Renaud Mahieux 1 and Antoine Gessain 1 Address 1Unité d Epidémiologie et Physiopathologie des Virus Oncogènes Institut Pasteur 28 rue du Dr Roux 75015 Paris France and 2Laboratoire ERMES IRD Technoparc Orléans cedex 2 France Email Sara Calattini - scalatt@pasteur.fr Sébastien Alain Chevalier - schevali@pasteur.fr Renan Duprez - rduprez@pasteur.fr Sylviane Bassot - sybassot@pasteur.fr Alain Froment - afroment@anth.umd.edu Renaud Mahieux - rmahieux@pasteur.fr Antoine Gessain - agessain@pasteur.fr Corresponding author fEqual contributors Published 09 May 2005 Received 20 April 2005 Retrovirology 2005 2 30 doi l0.ll86 l742-4690-2-30 Accepted 09 May 2005 This article is available from http www.retrovirology.cOm content 2 1 30 2005 Calattini et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Human T-cell Leukemia virus type 1 HTLV-1 and type 2 HTLV-2 are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have simian counterparts STLV-1 and STLV-2 . STLV-3 belongs to a third group of lymphotropic viruses which infect numerous African monkeys species. Among 240 Cameroonian plasma tested for the presence of HTLV-1 and or HTLV-2 antibodies 48 scored positive by immunofluorescence. Among those 27 had indeterminate western-blot pattern. PCR amplification of pol and tax regions using HTLV-1 -2 and STLV-3 highly conserved primers demonstrated the presence of a new human retrovirus in one DNA sample. tax 180 bp and pol 318 bp phylogenetic analyses
