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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Formulas Vasopressin in vasodilatory shock: is the heart in danger? | Available online http ccforum.eom content 12 2 132 Commentary Vasopressin in vasodilatory shock is the heart in danger Balazs Hauser1 4 Pierre Asfar2 Enrico Calzia1 Regent Laporte3 Michael Georgieff1 and Peter Radermacher1 1Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Universitatsklinikum Parkstrasse 11 89073 Ulm Germany 2Laboratoire HIFIH UPRES-EA 3859 IFR 132 Université d Angers Departement de Réanimation Médicale CHU 4 rue Larrey 49993 Angers Cedex 9 France 3Ferring Research Institute Inc Building 2 Room 439 3550 General Atomics Court San Diego CA 92121 USA 4Present address Aneszteziológiai és Intenziv Terápiás Klinika Semmelweis Egyetem H-1125 Kútvõlgyi út 4 Budapest Hungary Corresponding author Peter Radermacher peter.radermacher@uni-ulm.de Published 10 April 2008 This article is online at http ccforum.com content 12 2 132 2008 BioMed Central Ltd Critical Care 2008 12 132 doi 10.1186 cc6839 See related research by Muller et al. http ccforum.com content 12 1 R20 Abstract In patients with hyperdynamic hemodynamics infusing arginine vasopressin AVP in advanced vasodilatory shock is usually accompanied by a decrease in cardiac output and in visceral organ blood flow. Depending on the infusion rate this vasoconstriction also reduces coronary blood flow despite an increased coronary perfusion pressure. In a porcine model of transitory myocardial ischemia-induced left ventricular dysfunction Muller and colleagues now report that the AVP-related coronary vasoconstriction may impede diastolic relaxation while systolic contraction remains unaffected. Although any AVP-induced myocardial ischemia undoubtedly is a crucial safety issue these findings need to be discussed in the context of the model design the dosing of AVP as well as the complex direct afterload-independent and systemic vasoconstriction-related effects on the heart. In the previous issue of Critical Care Muller and colleagues reported that arginine vasopressin AVP either 0.005 U kg
