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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Unusual presentation of eosinophilic fasciitis: two case reports and a review of the literature | Danis et al. Journal of Medical Case Reports 2010 4 46 http www.jmedicalcasereports.eom content 4 1 46 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Unusual presentation of eosinophilic fasciitis two case reports and a review of the literature Ramazan Danis1 Sami Akbulut2 Abdullah Altintas3 Sehmus Ozmen1 Cihan Akgul Ozmen4 Abstract Introduction Eosinophilic fasciitis is an uncommon disorder with unknown etiology and a poorly understood pathogenesis. We present the cases of two patients with eosinophilic fasciitis with unusual presentation and describe the clinical characteristics and laboratory findings related to them. Case presentation The first case involves a 29-year-old Turkish man admitted with pain edema and induration of his right-upper and left-lower limbs. Unilateral edema and stiffness with prominent pretibial edema was noted upon physical examination. A high eosinophil count was found on the peripheral smear. The second case involves a 63-year-old Turkish man who had pain edema erythema and itching on his upper and lower extremities which developed after strenuous physical activity. He had cervical lymphadenopathy and polyarthritis upon physical examination and rheumatoid factor and antinuclear antibody upon laboratory examination. Conclusion Eosinophilic fasciitis can present with various symptoms. When patients exhibit eosinophilia arthralgia and myalgia eosinophilic fasciitis should be considered as a possible diagnosis. Introduction Eosinophilic fasciitis EF is an uncommon disorder with unknown etiology and a poorly understood pathogenesis. It has symmetrical involvement and in its early phase is characterized by limb or trunk erythema and edema and later by collagenous thickening of the dermis and subcutaneous fascia. EF is a scleroderma-like syndrome that was first described in 1974 by Shulman in patients with diffuse fasciitis and eosinophilia 1-3 . This syndrome was later named EF by Rodnan et al. 2 . Its onset is typically .