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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. | Cough BioMed Central Research Open Access Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist V112220 in guinea-pig Sum Yee Leung 1 4 Akio Niimi2 Alison S Williams1 Puneeta Nath1 F-Xavier Blanc1 Q Thai Dinh3 and K Fan Chung1 Address Thoracic medicine National Heart Lung Institute Imperial College London UK 2Department of respiratory medicine Graduate school of medicine Kyoto University Japan 3Department of internal medicine Charite-Universitatsmedizin Berlin Berlin Germany and 4Department of respiratory medicine Chang Gung Memorial Hospital Kaohsiung medical centre Taiwan Email Sum Yee Leung - sumyeeleung@hotmail.com Akio Niimi - niimi@kuhp.kyoto-u.ac.jp Alison S Williams - alison.williams@imperial.ac.uk Puneeta Nath - puneeta.nath@novartis.com F-Xavier Blanc - xavier.blanc@bct.aphp.fr Q Thai Dinh - q-thai.dinh@charite.de K Fan Chung - f.chung@imperial.ac.uk Corresponding author Published 23 December 2007 Received 3 December 2006 Cough 2007 3 10 doi 10.1 186 1745-9974-3-10 Accepted 23 December 2007 This article is available from http www.coughjournal.cOm content 3 1 10 2007 Leung et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cough reflex can be induced by the pepper extract capsaicin and by low pH in guinea-pig airways. Transient receptor potential vanniloid-1 TPRV-1 is expressed in the sensory and afferent nerve fibres in airways. Objective We hypothesized that a novel pyridazinylpiperazine analog TPRV-1 inhibitor can effectively reduce cough reflex stimulated by citric acid and capsaicin. Methods Guinea pigs were injected with specific TPRV-1 inhibitor V112220 a pyridazinylpiperazine analog of N- 4-tertiarybutylphenyl -4- 3-chloropyridin-2-yl tetrahydropyrazine-1 .
