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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Change in bronchial responsiveness and cough reflex sensitivity in patients with cough variant asthma: effect of inhaled corticosteroids. | Cough BioMed Central Research Open Access Change in bronchial responsiveness and cough reflex sensitivity in patients with cough variant asthma effect of inhaled corticosteroids Masaki Fujimura Johsuke Hara and Shigeharu Myou Address Respiratory Medicine Cellular Transplantation Biology Kanazawa University Graduate School of Medicine Kanazawa Japan Email Masaki Fujimura - fujimura@med3.m.kanazawa-u.ac.jp Johsuke Hara - hara@med3.m.kanazawa-u.ac.jp Shigeharu Myou - myous@nifty.com Corresponding author Published 25 August 2005 Received 05 April 2005 Cough 2005 1 5 doi 10.1186 1745-9974-1-5 Accepted 25 August 2005 This article is available from http www.coughjournal.cOm content 1 1 5 2005 Fujimura et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cough variant asthma CVA is a cause of chronic cough and a precursor of typical asthma. We retrospectively examined the longitudinal change in bronchial responsiveness and cough reflex sensitivity in CVA patients with respect to the effect of long-term inhaled corticosteroids ICS . Methods Provocative concentration of methacholine causing a 20 fall in forced expiratory volume in one second PC20-FEV1 and provocative concentration of capsaicin eliciting 5 or more coughs C5 were measured before treatment and during a follow up period following relief of cough median 2.0 range 0.5 to 8.0 years after the initial visit in a total of 20 patients with CVA 7 males and 13 females mean SD age of 49.9 12.9 years . Results Three of 8 patients not taking long-term ICS developed typical asthma compared to none of 12 patients taking ICS p 0.0171 . PC20-FEV1 significantly p 0.0001 increased from 1.80 GSEM 1.35 to 10.7 GSEM 1.63 mg ml in patients taking ICS but did not change in
