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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Anti-inflammatory effects of antidepressant and atypical antipsychotic medication for the treatment of major depression and comorbid arthritis: a case report | Baune and Eyre Journal of Medical Case Reports 2010 4 6 http www.jmedicalcasereports.eom content 4 1 6 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Anti-inflammatory effects of antidepressant and atypical antipsychotic medication for the treatment of major depression and comorbid arthritis a case report Bernhard T Baune Harris Eyre Abstract Introduction This case report describes the effects of psychotropic treatment quetiapine in particular on systemic inflammation pain general functioning and major depression in the treatment of a woman with arthritis. Case presentation A 49-year-old Caucasian Australian woman with arthritis pain and depression was treated with a course of escitalopram mirtazapine and quetiapine. Pain levels general functioning and degree of depressive symptoms were evaluated with a visual analogue scale. Systemic inflammation had been assessed by C-reactive protein serum levels since 2003. C-reactive protein levels physical pain symptoms of arthritis and depression decreased significantly during the past 12 months of treatment with quetiapine while treatment with selective serotonin reuptake inhibitors and mirtazapine remained the same. Conclusions We suggest that the treatment particularly with quetiapine may have anti-inflammatory effects in arthritis and comorbid major depression which eventually led to a remission of pain and depression and to normal general function. Introduction Patients with major depression often suffer comorbid physical disorders 1 of which some are related to systemic inflammation such as cardiovascular disease 2 and rheumatoid arthritis 3 . In turn systemic inflammation has been related to the onset and course of depression 4 . It has been suggested that stress and inflammatory pathways are involved in the response to antidepressant treatment 5 . In this case report we describe a patient with chronic psoriatic arthritis that cause impairing pain increased C-reactive protein levels CRP and depressive
