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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex,. | Retrovirology BioMed Central Research HTLV-1 Tax mutants that do not induce G arrest are disabled in activating the anaphase promoting complex Randall Merling Chunhua Chen Sohee Hong Ling Zhang Meihong Liu Yu-Liang Kuo and Chou-Zen Giam Open Access Address Department of Microbiology and Immunology Uniformed Services University of the Health Sciences 4301 Jones Bridge Rd. Bethesda MD 20814 USA Email Randall Merling - rmerling@usuhs.mil Chunhua Chen - chchen@usuhs.mil Sohee Hong - shong@usuhs.mil Ling Zhang - lingzhang@usuhs.mil Meihong Liu - meliu@usuhs.mil Yu-Liang Kuo - ykuo@usuhs.mil Chou-Zen Giam - cgiam@usuhs.mil Corresponding author Published 29 May 2007 Received 31 January 2007 Retrovirology 2007 4 35 doi 10.1186 1742-4690-4-35 Accepted 29 May 2007 This article is available from http www.retrovirology.cOm content 4 1 35 2007 Merling et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract HTLV-1 Tax is a potent activator of viral transcription and NF-kB. Recent data indicate that Tax activates the anaphase promoting complex cyclosome APC C ahead of schedule causing premature degradation of cyclin A cyclin B1 securin and Skp2. Premature loss of these mitotic regulators is accompanied by mitotic aberrations and leads to rapid senescence and cell cycle arrest in HeLa and s. cerevisiae cells. Tax-induced rapid senescence tax-IRS of HeLa cells is mediated primarily by a dramatic stabilization of p27KIP and is also accompanied by a great surge in the level of p21CIP mRNA and protein. Deficiencies in p27KIP prevent Tax-IRS. A collection of tax point mutants that permit normal growth of s. cerevisiae have been isolated. Like wild-type tax many of them C23W A108T L159F and L235F transactivate both the HTLV-LTR and the .