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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Video of dantrolene effectiveness on neuroleptic malignant syndrome associated muscular rigidity and tremor. | Available online http ccforum.eom content 11 3 415 Letter Video of dantrolene effectiveness on neuroleptic malignant syndrome associated muscular rigidity and tremor Miran Brvar1 2 and Matjaz Bunc2 3 1 Poison Control Centre University Medical Centre Ljubljana Ljubljana Slovenia institute for Pathophysiology Medical Faculty Zaloska cesta 4 1000 Ljubljana Slovenia 3Department for Cardiology University Medical Center Ljubljana Zaloska cesta 7 Ljubljana Slovenia Corresponding author Miran Brvar miran.brvar@kclj.si Published 1 June 2007 This article is online at http ccforum.com content 11 3 415 2007 BioMed Central Ltd Critical Care 2007 11 415 doi 10.1186 cc5907 Neuroleptic malignant syndrome NMS is an uncommon but potentially fatal adverse reaction to neuroleptic drugs including amisulpride 1 2 . NMS most commonly presents with increased body temperature muscular rigidity of a lead pipe nature altered mental status and autonomic dysfunction. Other extrapyramidal movement disorders such as tremor and cogwheel phenomena are also frequently present. The treatment of NMS includes discontinuation of contributing drugs and supportive therapy but specific treatment with dantrolene bromocriptine nondepolarizing neuromuscular paralysis and benzodiazepines among other such agents has been reported only anecdotally. A recent analysis of published case reports 3 evaluated the efficacy of dantrolene in NMS it found that dantrolene given as monotherapy might be helpful in managing this syndrome if the premedication was a neuroleptic monotherapy. We present video evidence of the effectiveness of dantrolene in reducing muscular rigidity tremor and cogwheel phenomena in a patient with NMS. Amisulpride therapy was initiated in a 79-year-old patient with a schizoaffective disorder. After 10 days the patient became somnolent with a high body temperature 40.3 C diaphoresis tachycardia rigid skeletal muscles of a lead pipe character cogwheel phenomena and resting tremor video footage is .
