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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Glutamine induces heat-shock protein and protects against Escherichia coli lipopolysaccharide-induced vascular hyporeactivity in rats. | Available online http ccforum.eom content 11 2 R34 Research Glutamine induces heat-shock protein and protects against Escherichia coli lipopolysaccharide-induced vascular hyporeactivity in rats Liang Jing Qiong Wu and Fuzhou Wang Department of Anesthesiology Zhongda Hospital and School of Clinical Medicine Southeast University 87 Ding Jia Qiao Rd. Nanjing Jiangsu China Corresponding author Liang Jing jinglg@gmail.com Received 6 Dec 2006 Revisions requested 16 Jan 2007 Revisions received 3 Feb 2007 Accepted 9 Mar 2007 Published 9 Mar 2007 Critical Care 2007 11 R34 doi 10.1186 cc5717 This article is online at http ccforum.com content 11 2 R34 2007 Jing et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Vascular hyporeactivity is an important problem associated with sepsis. Although the mechanism involves inflammatory pathway activation specific therapeutic approaches have not been defined. Glutamine Gln has been shown to provide some anti-inflammatory effects and improve outcomes in sepsis. Here we tested the hypothesis that Gln could reduce Escherichia coli lipopolysaccharide LPS -induced vascular hyporeactivity and evaluated the role of heatshock protein 70 HSP70 induction in this process. Methods Twenty-four male Sprague-Dawley rats were divided into control LPS shock and alanyl-Gln dipeptide LPS shock Ala-Gln LPS groups. Six hours after administration of LPS phenylephrine PE 0.5 to approximately 2.5 ựg kg was applied intravenously to all groups and the percentage increase in mean arterial pressure MAP was detected in the respective groups. The concentration-response curve of PE was obtained in tension experiments and the average values of PE maximum efficacy Emax and median effective
