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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical review: Patient-ventilator interaction in chronic obstructive pulmonary disease. | Available online http ccforum.eom content 10 6 236 Review Clinical review Patient-ventilator interaction in chronic obstructive pulmonary disease Philippe Jolliet1 and Didier Tassaux1 2 intensive Care University Hospital 1211 Geneva 14 Switzerland 2Anesthesiology University Hospital 1211 Geneva 14 Switzerland Corresponding author Philippe Jolliet jolliet@medecine.unige.ch Published 3 November 2006 Critical Care 2006 10 236 doi 10.1186 cc5073 This article is online at http ccforum.com content 10 6 236 2006 BioMed Central Ltd Abstract Mechanically ventilated patients with chronic obstructive pulmonary disease often prove challenging to the clinician due to the complex pathophysiology of the disease and the high risk of patientventilator asynchrony. These problems are encountered in both intubated patients and those ventilated with non-invasive ventilation. Much knowledge has been gained over the years in our understanding of the mechanisms underlying the difficult interaction between these patients and the machines used to provide them with the ventilatory support they often require for prolonged periods. This paper attempts to summarize the various key issues of patient-ventilator interaction during pressure support ventilation the most often used partial ventilatory support mode and to draw clinicians attention to the need for sufficient knowledge when setting the ventilator at the bedside given the often conflicting goals that must be met. Introduction In patients with chronic obstructive pulmonary disease COPD mechanical ventilation both invasive MV and non-invasive NIV often proves challenging due to the interaction between the various pathophysiological mechanisms of the disease and the goals of ventilatory support 1 2 . Thanks to increased knowledge gained over the years the severe complications associated with dynamic hyperinflation and intrinsic positive end-expiratory pressure PEEPi 3 first described over 20 years ago 4 have become less frequent 2 3 . .