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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Rapid generation of an anthrax immunotherapeutic from goats using a novel non-toxic muramyl dipeptide adjuvant. | Journal of Immune Based Therapies and Vaccines Original research BioMed Central Open Access Rapid generation of an anthrax immunotherapeutic from goats using a novel non-toxic muramyl dipeptide adjuvant Cassandra D Kelly1 2 Chris O Loughlin3 Frank B Gelder3 Johnny W Peterson4 Laurie E Sower4 and Nick M Cirino 1 2 Address Wadsworth Center New York State Department of Health Biodefense Laboratory Albany NY USA 2SUNY at Albany School of Public Health Department of Biomedical Sciences Albany NY USA 3Virionyx Corporation Ltd Auckland NZ USA and 4The University of Texas Medical Branch Galveston TX USA Email Cassandra D Kelly - cdk01@health.state.ny.us Chris O Loughlin - c.oloughlin@virionyx.com Frank B Gelder - f.gelder@virionyx.com Johnny W Peterson - jpeterso@utmb.edu Laurie E Sower - lsower@utmb.edu Nick M Cirino - ncirino@wadsworth.org Corresponding author Published 22 October 2007 Journal of Immune Based Therapies and Vaccines 2007 5 11 doi 10.1186 1476-8518-5- 11 Received 24 July 2007 Accepted 22 October 2007 This article is available from http www.jibtherapies.cOm content 5 1 11 2007 Kelly et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background There is a clear need for vaccines and therapeutics for potential biological weapons of mass destruction and emerging diseases. Anthrax caused by the bacterium Bacillus anthracis has been used as both a biological warfare agent and bioterrorist weapon previously. Although antibiotic therapy is effective in the early stages of anthrax infection it does not have any effect once exposed individuals become symptomatic due to B. anthracis exotoxin accumulation. The bipartite exotoxins are the major contributing factors to the morbidity and mortality observed in acute .
