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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: An uncommon presentation and course of metastatic malignant melanoma: a case report | Journal of Medical Case Reports BioMed Central Case report Open Access An uncommon presentation and course of metastatic malignant melanoma a case report Astrid Dalhaug1 Adam Pawinski1 Jan Norum2 3 and Carsten Nieder 1 3 Address 1Radiation Oncology Unit Department of Internal Medicine and Skin Diseases Nordlandssykehuset HF 8092 Bod0 Norway 2Department of Oncology University Hospital of North Norway Tromso Norway and institute of Clinical Medicine Faculty of Medicine University of Tromso Tromso Norway Email Astrid Dalhaug - astrid.dalhaug@nlsh.no Adam Pawinski - adam.pawinski@nlsn.no Jan Norum - jan.norum@unn.no Carsten Nieder - carsten.nieder@nlsh.no Corresponding author Published 26 November 2007 Received 19 September 2007 Accepted 26 November 2007 Journal of Medical Case Reports 2007 1 151 doi l0.ll86 l 752-I947-I-I5I r This article is available from http www.jmedicalcasereports.cOm content 1 1 151 2007 Dalhaug et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Most patients with brain metastases from malignant melanoma are diagnosed after treatment for known extracranial metastases and have a poor outcome despite various local and systemic therapeutic approaches. Here we discuss an unusual case where a 45-year old patient presented with a brain metastasis as the first symptom of disease and where the presumed primary lesion later was found in the gastro-intestinal tract. Treatment consisted of sequential surgical removal of a total of 4 tumor sites 2 extracranially whole-brain radiotherapy and two radiosurgery procedures within 13 months. Following her last treatment the patient has now been in remission for 20 months. This case illustrates that some patients with multi-organ melanoma manifestations may .
