Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant. | Journal of Immune Based Therapies and Vaccines Original research BioMed Central Open Access Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6 11 16 and 18 Ll-virus-like particles formulated with or without Merck aluminum adjuvant Wanda Ruiz1 William L McClements2 Kathrin U Jansen2 and MarkT Esser 1 Address 1Vaccine and Biologics Research Merck Research Laboratories 466 Devon Park Dr. Wayne PA 19087-8630 USA and 2Vaccine and Biologics Research Merck Research Laboratories West Point PA 19486 USA Email Wanda Ruiz - wanda_ruiz@merck.com William L McClements - william_mcclements@merck.com Kathrin U Jansen - jansen@mac.com MarkT Esser - mark_esser@merck.com Corresponding author Published 20 April 2005 Received 03 March 2005 Journal of Immune Based Therapies and Vaccines 2005 3 2 doi 10.1 186 1476-8518-3-2 Accepted 20 Apn I 2005 This article is available from http www.jibtherapies.cOm content 3 1 2 2005 Ruiz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human papillomaviruses HPV are the most common sexually transmitted viruses. Infection of the cervical epithelium by HPVs can lead to the development of cervical cancer. Recent advances in vaccine research have shown that immunization with papillomavirus-like particles VLPs containing the major structural viral protein L1 from HPV 16 can provide protection from the establishment of a chronic HPV 16 infection and related cervical intraepithelial neoplasia CIN in baseline HPV 16 naive women. Methods To better understand the quantitative and qualitative effects of aluminum adjuvant on the immunogenic properties of an HPV 6 11 16 and 18L1 VLP vaccine we used an HPV-specific antibody isotyping assay