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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: New horizons: NT-proBNP for risk stratification of patients with shock in the intensive care unit. | Available online http ccforum.eom content 10 2 134 Commentary New horizons NT-proBNP for risk stratification of patients with shock in the intensive care unit Ursula Hoffmann Martin Borggrefe and Martina Brueckmann 1st Department of Medicine Faculty of Clinical Medicine Mannheim University of Heidelberg Mannheim Germany Corresponding author Hoffmann Ursula Ursula.Hoffmann@med.ma.uni-heidelberg.de Published 29 March 2006 This article is online at http ccforum.com content 10 2 134 2006 BioMed Central Ltd Critical Care 2006 10 134 doi 10.1186 cc4883 See related research by Januzzi et al. in issue 10.1 http ccforum.com content 10 1 R37 Abstract B-type natriuretic peptide BNP and amino-terminal pro-BNP NT-proBNP are promising cardiac biomarkers that have recently been shown to be of diagnostic value in decompensated heart failure acute coronary syndromes and other conditions resulting in myocardial stretch and volume overload. In view of the high prevalence of cardiac disorders in the intensive care unit the experience of elevated natriuretic peptide levels in the critically ill might be of enormous diagnostic and therapeutic value. BNP and NT-proBNP levels rise to different degrees in critical illness and may also serve as markers of severity and prognosis in diseases beyond acute or chronic heart failure. The diagnostic and prognostic use of natriuretic peptides in the intensive care setting for patients with various forms of shock could be an attractive alternative as noninvasive markers of cardiac dysfunction that could obviate the need for pulmonary artery catheterization in some patients. In a recent issue of Critical Care Januzzi and coworkers 1 report the results of a prospective cohort study evaluating natriuretic peptides in various shock patients in the intensive care unit ICU . The authors found no correlation between elevated levels of amino-terminal pro-BNP NT-proBNP and high filling pressures among patients with shock within the ICU but higher values were
