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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Development of a model of focal pneumococcal pneumonia in young rats. | Journal of Immune Based Therapies and Vaccines Original research BioMed Central Open Access Development of a model of focal pneumococcal pneumonia in young rats Richard Malley 1 2 Anne M Stack1 Robert N Husson2 Claudette M Thompson3 Gary R Fleisher1 and Richard A Saladino1 4 Address 1Division of Emergency Medicine Children s Hospital Harvard Medical School Boston MA USA 2Division of Infectious Diseases Children s Hospital Harvard Medical School Boston MA USA 3Harvard School of Public Health Boston MA USA and 4Division of Pediatric Emergency Medicine Department of Pediatrics Children s Hospital Pittsburgh PA USA Email Richard Malley - richard.malley@childrens.harvard.edu Anne M Stack - anne.stack@childrens.harvard.edu Robert N Husson - robert.husson@childrens.harvard.edu Claudette M Thompson - cthompso@hsph.harvard.edu Gary R Fleisher - gary.fleisher@childrens.harvard.edu Richard A Saladino - saladir@chplink.chp.edu Corresponding author Published 23 January 2004 Received 02 December 2003 Journal of Immune Based Therapies and Vaccines 2004 2 2 This article is available from http www.jibtherapies.com content 2 l 2 Accepted 23 January 2004 2004 Malley et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background A recently licensed pneumococcal conjugate vaccine has been shown to be highly effective in the prevention of bacteremia in immunized children but the degree of protection against pneumonia has been difficult to determine. Methods We sought to develop a model of Streptococcus pneumoniae pneumonia in Sprague-Dawley rats. We challenged three-week old Sprague-Dawley pups via intrapulmonary injection of S. pneumoniae serotypes 3 and 6B. Outcomes included bacteremia mortality as well histologic sections of the lungs. Results Pneumonia was reliably produced in animals receiving
