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Retrovirology Research BioMed Central Open Access APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression Joel A Vázquez-Pérez, Christopher E Ormsby, Ramón Hernández-Juan, Klintsy J Torres and Gustavo Reyes-Terán* Address: Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, México City, México Email: Joel A Vázquez-Pérez - joevazpe@prodigy.net.mx; Christopher E Ormsby - christopher.ormsby@cieni.org.mx; Ramón HernándezJuan - ramon.hernandez@cieni.org.mx; Klintsy J Torres - klintsy@gmail.com; Gustavo Reyes-Terán* - reyesteran@cieni.org.mx * Corresponding author Published: 2 March 2009 Retrovirology 2009, 6:23 doi:10.1186/1742-4690-6-23 Received: 23 December 2008 Accepted: 2 March 2009 This article is available from: http://www.retrovirology.com/content/6/1/23 © 2009 Vázquez-Pérez et. | Retrovirology BioMed Central Research APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression Joel A Vázquez-Pérez Christopher E Ormsby Ramón Hernández-Juan Klintsy J Torres and Gustavo Reyes-Terán Open Access Address Centro de Investigation en Enfermedades Infecciosas Instituto National de Enfermedades Respiratorias Mexico City Mexico Email Joel A Vázquez-Pérez - joevazpe@prodigy.net.mx Christopher E Ormsby - christopher.ormsby@cieni.org.mx Ramón Hernandez-Juan - ramon.hernandez@cieni.org.mx Klintsy J Torres - klintsy@gmail.com Gustavo Reyes-Terán - reyesteran@cieni.org.mx Corresponding author Published 2 March 2009 Received 23 December 2008 Accepted 2 March 2009 Retrovirology 2009 6 23 doi l0.ll86 l 742-4690-6-23 This article is available from http www.retrovirology.com content 6 1 23 2009 Vázquez-Pérez et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background APOBEC3G is an antiretroviral factor that acts by inducing G to A mutations. In this study we examined the expression of APOBEC3G in uninfected HIV-1 exposed individuals at the time of their partner s diagnosis and one year later. We then compared this expression with that of infected individuals at different disease stages. APOBEC3G mRNA was measured in PBMCs from three groups healthy controls with no known risk factor to HIV infection n 26 exposed uninfected individuals who had unprotected sex with their HIV partners for at least 3 months n 37 and HIV infected patients at various disease stages n 45 including 8 patients with low HIV viral loads 10 000 copies mL LVL for at least 3 years. Additionally we obtained sequences from the env gag pol nef vif .
