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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Stimulation with Peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytes. | Journal of Inflammation BioMed Central Research Stimulation with Peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytes Kolapo M Ajuwon 1 William Banz2 4 and Todd A Winters2 Open Access Address Department of Animal Sciences Purdue University West Lafayette IN 47907 USA and 2Department of Animal Science Food and Nutrition Southern Illinois University Carbondale IL 62901 USA Email Kolapo M Ajuwon - kajuwon@purdue.edu William Banz - banz@siu.edu Todd A Winters - tw3a@siu.edu Corresponding author Published 6 April 2009 Received 14 July 2008 Journal of Inflammation 2009 6 8 doi 10.1 186 1476-9255-6-8 Accepted 6 April 2009 This article is available from http www.journal-inflammation.cOm content 6 1 8 2009 Ajuwon et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inflammation is a major component of obesity and diabetes and toll-like receptors TLRs play critical roles in the regulation of inflammation and response to pathogen associated molecular patterns PAMPs and fatty acids in. Although immune cells such as macrophages are primarily responsible for recognition and clearance of pathogens adipocytes are also closely involved in the regulation of innate immunity and inflammation. Whereas it has been demonstrated that adipocytes respond to TLR4 stimulation with lipopolysacccharide very little is known about their response to the TLR2 agonist peptidoglycan. Methods We investigated the response to peptidoglycan from Staphylococcus aureus in differentiated 3T3-L1 adipocytes. Real-time PCR analysis was used to quantify the expression of interleukin 6 IL6 adiponectin receptors adipoR1 and adipoR2 toll-like .
