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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Perfluorochemical (PFC) liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10) expression in rodent lung. | Journal of Inflammation BioMed Central Open Access Perfluorochemical PFC liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 AdvIL-10 expression in rodent lung John T Li 1 2 Laura A Bonneau4 Jerry J Zimmerman2 and Daniel J Weiss3 Address University of California San Francisco Moffitt M-680 505 Parnassus Ave. San Francisco CA 94143 USA 2Seattle Children s Hospital Regional Medical Center B-9524 Critical Care 4800 Sand Point Way NE Seattle WA 98105 USA 3University of Vermont room 226C HSRF 149 Beaumont Ave. Burlington VT 05405 USA and 4University of Wisconsin School of Medicine Health Sciences 750 Highland Ave. Madison WI 53705 USA Email JT Li - John.Li@ucsf.edu LA Bonneau - laura@fordpinto.com JJ Zimmerman - jerry.zimmerman@seattlechildrens.org DJ Weiss - daniel.weiss@UVM.edu Corresponding author Published I May 2007 Received 5 May 2005 Journal of Inflammation 2007 4 9 doi 10.1186 1476-9255-4-9 Accepted 1 May 2007 This article is available from http www.journal-inflammation.cOm content 4 1 9 2007 Li et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Adenovirus and cationic liposome mediated transfer of Interleukin-1 0 IL-10 a potent antiinflammatory cytokine has been shown to decrease pro-inflammatory cytokine levels and overall lung inflammation in models of lung transplantation and injury. Limitations to current approaches of IL-10 gene therapy include poor vector delivery methods and pro-inflammatory properties of human IL-10 under certain conditions. We hypothesize that using perfluorochemical PFC liquid to deliver the highly homologous viral IL-10 vIL-10 which is predominantly anti-inflammatory with minimal .
