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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prospects for control of emerging infectious diseases with plasmid DNA vaccines. | Journal of Immune Based Therapies and Vaccines BioMed Central Open Access Review Prospects for control of emerging infectious diseases with plasmid DNA vaccines Ronald B Moss1 2 Address 1Vical Inc. San Diego CA USA and 2NexBio Inc San Diego CA USA Email Ronald B Moss - shotdoc92130@yahoo.com Published 7 September 2009 Received 17 August 2009 _ _D__J u. . mno j.MAiio njvz oriovi Accepted 7 September 2009 Journal ofImmune Based Therapies and Vaccines 2009 7 3 doi l0.ll86 l476-85l8-7-3 This article is available from http www.jibtherapies.cOm content 7 l 3 2009 Moss licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Experiments almost 20 years ago demonstrated that injections of a sequence of DNA encoding part of a pathogen could stimulate immunity. It was soon realized that DNA vaccination had numerous potential advantages over conventional vaccine approaches including inherent safety and a more rapid production time. These and other attributes make DNA vaccines ideal for development against emerging pathogens. Recent advances in optimizing various aspects of DNA vaccination have accelerated this approach from concept to reality in contemporary human trials. Although not yet licensed for human use several DNA vaccines have now been approved for animal health indications. The rapid manufacturing capabilities of DNA vaccines may be particularly important for emerging infectious diseases including the current novel HlNl Influenza A pandemic where preexisting immunity is limited. Because of recent advances in DNA vaccination this approach has the potential to be a powerful new weapon in protecting against emerging and potentially pandemic human pathogens. Throughout recorded history infectious .
