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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical review: Influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock. | Critical Care June 2004 Vol 8 No 3 Asfar et al. Review Clinical review Influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock Pierre Asfar1 Daniel De Backer2 Andreas Meier-Hellmann3 Peter Radermacher4 and Samir G Sakka5 1Staff Physician Département de Réanimation Médicale Centre Hospitalier Universitaire Angers France 2Staff Physician Département de Réanimation Médicale Hôpital Erasme Université Libre Bruxelles Belgium 3Head Klinik fur Anasthesie Intensivmedizin und Schmerztherapie Helios Klinikum Erfurt Germany 4Section Head Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Universitatsklinikum Ulm Germany 5Staff Physician Department of Anesthesiology and Intensive Care Medicine Friedrich-Schiller University Jena Germany Correspondence Peter Radermacher peter.radermacher@medizin.uni-ulm.de Published online 29 December 2003 This article is online at http ccforum.com content 8Z3 170 2004 BioMed Central Ltd Critical Care 2004 8 170-179 DOI 10.1186 cc2418 Abstract The organs of the hepato-splanchnic system are considered to play a key role in the development of multiorgan failure during septic shock. Impaired oxygenation of the intestinal mucosa can lead to disruption of the intestinal barrier which may promote a vicious cycle of inflammatory response increased oxygen demand and inadequate oxygen supply. Standard septic shock therapy includes supportive treatment such as fluid resuscitation administration of vasopressors adrenergic and nonadrenergic drugs and respiratory and renal support. These therapies may have beneficial or detrimental effects not only on systemic haemodynamics but also on splanchnic haemodynamics at both the macrocirculatory and microcirculatory levels. This clinical review focuses on the splanchnic haemodynamic and metabolic effects of standard therapies used in patients with septic shock as well as on the recently described nonconventional therapies such as .